To explore whether H2A.XY142ph was enrolled in the Livin-mediated autophagy induced by starvation in colon cancer cells, H2A.X−/−Livin+/+ SW480 cells were co-transfected with H2A.XWT or H2A.XY142F plasmid and LC3 EGFP-tagged plasmid. Here, MAP1LC3A is linked to colonic neoplasm.