In order to get a finer characterization of the tumor-targeting properties of our products, we compared IL2-XE114-TNFmut and IL2-F8-TNFmut (an analog specific to the alternatively-spliced EDA domain of fibronectin) (Supplementary Figure 4) in mice bearing murine CT26 tumors, that had been stably-transfected for CAIX expression on the cell surface (30). Here, FN1 is linked to neoplasm.