VEGFA and cancer: The most characteristic target is vascular endothelial growth factor (VEGF), where anti-VEGF therapy, such as bevacizumab, a humanized monoclonal anti-VEGF antibody, or sorafenib and sunitinib, VEGF receptor tyrosine kinase inhibitors, were incorporated in anti-cancer treatment options either as single agents or adjuvant therapy (3, 4).