In order to find key nodes of the miRNA signature model regulating colorectal cancer 10 hub genes (ESR1, ADCY9, MEF2C, NRXN1, ADCY5, FGF2, KITLG, GATA1, GRIA1, KAT2B) were screened according to Cytoscape 3.6.1 and its plug-in (degree ranking of cytoHubba). This evidence concerns the gene MEF2C and colorectal cancer.