By comparing the RNA profiles of TANs and the CD11b+/GR1+ MDSC granulocytic fraction from tumor bearing mice with bone-marrow naïve neutrophils from non-tumor-bearing animals, used as baseline control, Fridlender and colleagues showed that genetic profiles of TANs, neutrophils and granulocyte precursors differ markedly. The gene discussed is ITGAM; the disease is neoplasm.