In mouse models of spontaneous breast cancer metastasis, the neutralization of IL-17 or G-CSF and the absence of γδ T cells prevented neutrophil accumulation and down-regulated the T-cell-suppressive phenotype of neutrophils, the absence of γδ T cells or neutrophils reduces pulmonary and lymph node metastases without influencing primary tumor progression (30). Here, CSF3 is linked to breast cancer.