FOXO1 and cancer: The other main pathway was pathway in cancer, and the genes in this pathway can impact tumor cell proliferation (PPARG, RAF1), regulate hepatic glucose and lipid metabolism (FOXO1), and decrease the viability and invasiveness of HCC cells (RALA) (Ezzeldin et al., 2014; O-Sullivan et al., 2015; Jeric et al., 2016; Li et al., 2017; Savic et al., 2016).