P2RY12 and thrombotic disease: It is also known to inhibit the P2RY family of receptor proteins on the surface of platelets.34,35,50,51 By inhibiting P2RY12 function, clopidogrel indirectly suppresses platelet clustering and clot formation and prevents clots contributing to heart attack, stroke, and deep vein thrombosis.52–54P2RY1 works in concert with P2RY12 to promote platelet activation and aggregation.55 Consequently, P2YR1 variants have been associated with increased platelet response to adenosine 5’-diphosphate stimulation56 and increased expression may be linked to thrombotic disease.57