SOCS6 and Familial prostate cancer: In consistent with the putative tumor suppressor function of SOCS6, we found two naturally occurred SOCS6 mutations (K17N, reported in prostate cancer; E61Q, reported in head and neck cancer) reported in COSMIC somatic database (https://cancer.sanger.ac.uk/cosmic/) within its N-terminal Sin1-interacting region, which reduced SOCS6-Sin1 interaction and impaired SOCS6-mediated Sin1 degradation (Supplementary Fig. 4a–d).