AR and prostate adenocarcinoma: We further explored the gene expression data of TCGA, and interestingly found that, unlike the NEPC dataset which demonstrated a co-amplification of TNC with AR, MYC and ERG (Supplementary Figure 1), most of the prostate adenocarcinoma patients in TCGA having TNC alteration, did not show a significant co-amplification of AR, MYC and ERG, or co-expression of AR and ERG (Supplementary Figure 2).