In the present study, 40 DEGs were upregulated between the low- and high-RFI animals, which were mainly associated with immune pathways, including asthma, cell adhesion molecules, livestock influenza, the production of IgA intestinal immune network, type 1 diabetes, and inflammatory bowel disease, which showed that the high-RFI lambs had a heightened immune response. The gene discussed is CD79A; the disease is asthma.