ADRA2A and obesity due to melanocortin 4 receptor deficiency: Additionally, catecholamine-stimulated whole body lipolysis and lipolysis in subcutaneous adipocytes are blunted in obesity (Blaak et al., 1994; Large and Arner, 1998), thereby limiting lipid mobilization and favoring fat accumulation, which suggests that ADRA2A might be involved in fat and energy metabolism (Lima et al., 2007).