Additionally, catecholamine-stimulated whole body lipolysis and lipolysis in subcutaneous adipocytes are blunted in obesity (Blaak et al., 1994; Large and Arner, 1998), thereby limiting lipid mobilization and favoring fat accumulation, which suggests that ADRA2A might be involved in fat and energy metabolism (Lima et al., 2007). This evidence concerns the gene ADRA2A and obesity disorder.