Genes flanking ROR2, i.e., SPTLC1 (long-chain base subunit 1 of serine palmitoyltransferase) (Suh et al., 2014; Ho and Jerath, 2018), NFIL3 (interleukin 3-regulated nuclear factor) (Kobayashi et al., 2011; Kobayashi et al., 2014), and AUH (3-methylglutaconyl-CoA hydratase) (Ijlst et al., 2002; Ly et al., 2003) were excluded as potential candidates as they have been reported in humans or mice to be causative for hereditary sensory and autonomic neuropathy (type 1A), susceptibility to inflammatory bowel disease and 3-methylglutaconic aciduria (type 1), respectively. Here, ROR2 is linked to inflammatory bowel disease.