Molecular genetic analyses in humans have revealed that mutations in ROR2 cause dominant Brachydactyly type B and recessive Robinow Syndrome, with terminal limb malformations as common symptoms (Oldridge et al., 2000; Schwabe et al., 2000; Afzal et al., 2000; van Bokhoven et al., 2000; Bacchelli et al., 2003; Tufan et al., 2005; Ali et al., 2007; Brunetti-Pierri et al., 2008; Kjaer et al., 2009). Here, ROR2 is linked to brachydactyly type B.