This analysis indicated pathways, biological processes, and diseases associated with RASopathies that were enriched, which included the RAS, MAPK, RAP1, and PIK3-Akt signaling pathways and proteoglycans in cancer as well as congenital cardiac defects such as hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), and arrhythmogenic right ventricular cardiomyopathy (ARVC) as shown in Figure 1A. This evidence concerns the gene PIK3CG and cancer.