Moreover, WES has allowed the identification of new genes associated to the clinical description of patients with RASopathies (Niguidula et al., 2018; Matias et al., 2019), such as RIT1 (Aoki et al., 2013), A2ML1 (Vissers et al., 2015), RASA2, SPRY1 (Chen et al., 2014), SOS2, LZTR1 (Yamamoto et al., 2015; Umeki et al., 2019), PPP1CB (Gripp et al., 2016), CBL (Coe et al., 2017), and MRAS (Higgins et al., 2017), as well as new mutations in genes of the RAS/MAPK pathway (Carapito et al., 2014; Sana et al., 2016; Coe et al., 2017; Harms et al., 2018; Valera et al., 2018). This evidence concerns the gene RASA2 and RASopathy.