Some of the genetic factors of RA are associated with the alleles of HLA-DR4, DR14, and some DR1 beta chains (Smolen et al., 2016), which are polymorphisms found in the gene of protein tyrosine phosphatase and nonreceptor type 22 (PTPN22) that regulate the activity of T- and B-lymphocytes, as well as the polymorphisms of the genes that regulate cytokine production (TNF and STAT4) (Conigliaro et al., 2017). The gene discussed is TNF; the disease is rheumatoid arthritis.