ERBB2 and neoplasm: Since the initial description of this concept (73), the number of preclinical studies evaluating CAR-engineered NK-92 cells has steadily increased, demonstrating markedly enhanced antitumor activity of the cells if targeted to surface molecules expressed by different hematologic malignancies and solid tumors (15, 83), including tumor-associated antigens such as EGFR, EGFRvIII and ErbB2 that are relevant for the development of immunotherapies for glioblastoma (71, 125, 160) (outlined in the following section).