In vitro assays using hydrophobic peptides from the BH3 domain of the proteins Bax, Bad, and Bak, when binding them to the fusogenic peptide of the antennapedia protein to make them permeable to the tumor cells of head and neck squamous cell carcinoma, antagonized the activity of Bcl-XL and Bcl-2 and restored the apoptosis (25). This evidence concerns the gene BAX and head and neck squamous cell carcinoma.