BAX and neoplasm: In the tumor-bearing mice treated with the recombinant Salmonella strains, the presence of Salmonella bacilli that still produce recombinant proteins at day 26 (Figures 7A,B) confirms the S. enterica ability to reach the tumor microenvironment, and once there, express the cell-permeable Bax BH3 peptide through the MisL autotransporter system.