EGFR, a subtype of the ErbB receptors, which include EGFR (ErbB1, HER1), p185her2/neu (ErbB2, HER2), ErbB3 (HER3), and ErbB4 (HER4), can regulate cell motility and adhesion, adenoma invasion, angiogenesis, and adenoma cell proliferation (11). This evidence concerns the gene ERBB2 and adenoma.