Whereas, organic secondary hypogonadism (low-normal LH+FSH) is biochemically indistinguishable from non-gonadal illness effect, PH can be easily diagnosable even in the acute (or chronic) disease settings, subject to the potential for the LH+FSH rise being blunted with intercurrent illness and/or medication (especially opiates). The gene discussed is PLOD1; the disease is hypogonadism.