POMC and Alzheimer disease: Furthermore, a number of cardiometabolic disease risk genes, among them those encoding for apolipoprotein E, whose ε4-allele markedly increases the risk for Alzheimer’s dementia (AD) (13), transcription factor cAMP response element-binding protein (CREB), neuroplasticity marker brain-derived neurotrophic factor (BDNF), melatonin receptor 1B (MTNR1B), and proopiomelanocortin (POMC) (11), are known to be associated also with mood disorders.