We do not consider POMC per se a valuable drug target, mainly because of its involvement in a plethora of body functions which does not allow function-specific targeting, however, the DNAm status of POMC might possibly be suited as a (vulnerability) biomarker for MetS in patients with stress-related psychiatric disorders such as PTSD, in particular as it previously has been found associated with body weight regulation (83). The gene discussed is POMC; the disease is psychiatric disorder.