LTB4 has been reported, together with IL-8, among the chemoattractants involved in the recruitment of neutrophils in the airways, and its concentrations are increased in induced sputum from COPD subjects (Profita et al., 2005) and further increase during exacerbations (Biernacki et al., 2003). Here, CXCL8 is linked to chronic obstructive pulmonary disease.