ANXA1 and asthma: Studies by our group and other laboratories, using Anx-A1-null mice, hu-r-Anx-A1, neutralizing antibodies, and antisense agents, have demonstrated that this protein is responsible for many of the acute anti-inflammatory effects of glucocorticoids (D’Acquisto et al., 2008) and that its absence or degradation is implicated in the pathogenesis of asthma and airway hyperactivity (Chung et al., 2004; Ng et al., 2011).