The influence of the APOE genotype on clinical CADASIL features was investigated in two studies, but while in one increased white matter hyperintensity volumes in APOE2, but not APOE4 carriers were reported (Gesierich et al., 2015), in the other no association with MRI lesion volumes or disease phenotype (age of onset, presence of stroke) could be detected (Singhal et al., 2004). This evidence concerns the gene APOE and Stroke.