The administration of a CTHRC1-neutralizing inhibitor to a xenograft mouse model reduced the tumor burden and infiltration of Tie2-expressing monocytes (TEMs) in pancreatic tumor specimens, indicating that blocking the CTHRC1/angiopoietin-2 (Ang-2)/TEM axis during angiogenesis suppresses tumorigenesis [27]. This evidence concerns the gene ANGPT2 and neoplasm.