Recently, CTHRC1 overexpression was reported to be associated with MVD and to induce the migration and tube formation of human umbilical vein endothelial cells (HUVECs) by increasing the phosphorylation of extracellular-signal-regulated protein kinase (ERK) and c-Jun N-terminal kinase (JNK) in gastrointestinal stromal tumors [28]. This evidence concerns the gene MAPK8 and gastrointestinal stromal tumor.