In this study, we observed that CTHRC1 expression, an independent predictor of prognosis in LUAD, was positively associated with tumor angiogenesis markers, and the GSEA data provided more evidence that gene expression related to the promotion of angiogenesis was more activated in the high-CTHRC1 group with LUAD than in the low-CTHRC1 group. Here, CTHRC1 is linked to neoplasm.