As shown in Fig. 4a, lung adenocarcinoma cell lines, including A549, GLC-82, SPC-A1, PC9, H1299 and H1975, exhibited higher CTHRC1 levels compared to that of primary human normal lung epithelial cells (BEAS-2B) and non-adenocarcinoma cell lines (L78 and H460). The gene discussed is CTHRC1; the disease is lung adenocarcinoma.