PLD1 and Alzheimer disease: As a result, we assessed potentiation and found that 3xTg-AD mice that received chronic PLD1 inhibitor treatment showed significantly elevated HFS-LTP (*p < 0.05; Mann-Whitney U; Fig. 3B,C) compared to saline-treated siblings (Fig. 3C; Last 10 min responses - I: 267.000 ± 9.631 vs S: 146.100 ± 4.809 respectively), suggesting that the preservation of contextual memory seen in NOR and FC could be a consequence of preservation of synaptic function in the Schaffer collaterals.