PLD1 and Alzheimer disease: In the present study, we report that chronic inhibition with a PLD1 specific inhibitor (VU 0155069) is sufficient to prevent the cognitive deficits driven by progressive accumulation of oAβ and otau in the 6-month old 3xTg-AD mice, by (1) studying behavior (Figs. 1 and 2) to assess prevention of memory deficits, (2) electrophysiology (Fig. 3) looking at the prevention of synaptic dysfunction and finally (3) elucidating potential synaptic resilience via preservation of dendritic spines (Fig. 4).