PLD1 and Alzheimer disease: In order to assess the therapeutic potential, we rationalized that the effect of PLD1 inhibition can be effectively compared only in the pathological state and as a result, we used age-matched 3xTg-AD siblings injected with saline as the control group for the PLD1 inhibitor injected experimental group in the current studies, since PLD1 inhibition in wildtype mice does not affect memory18 (also see Suppl.