Furthermore, when comparing Ang-2 levels in Fontan patients to patients with hereditary hemorrhagic telangiectasia (HHT) and confirmed PAVMs, Ang-2 was found to be 4.2-fold higher in Fontan patients (8,875.4 ± 3,336.9 pg/mL) than in HHT patients with PAVMs (2,227.1 ± 968.5 pg/mL) as seen in Fig. 2B. Here, ANGPT2 is linked to hereditary hemorrhagic telangiectasia.