In addition, 2 pathways were observed in developmental biology including endoderm differentiation, 1 in immune system: negative regulation of MAPK pathway, 1 in cancer: photodynamic therapy-induced HIF-1 survival signalling, 1 in haemostasis, 1 in gene expression (transcription): TP53 regulates transcription of cell cycle genes, and 1 in transport of small molecules: bile salt and organic anion SLC transporters. Here, TP53 is linked to cancer.