In addition, the expression of seven orthologue genes affected after in vivo exposure were also found in vitro and were representative of the major effects of E171: immune system (BCL10, TNFAIP8L2, LRRC15), inflammation (LRRC15), signal transduction (TAS2R3), metabolism (BAAT, TNFAIP8L2, and BCL10), and cancer (WDR78). Here, TIPE2 is linked to cancer.