There were also genes that are of insignificant expression in tumor cells that increase in expression in KO cells, e.g. THBS3, IL2RG, SPRR3, TGM2, HMOX1 and TMEM62 or are lower in expression in tumor cells and significantly decreased in KO cells such as MAN1A1, CES1, STCBP6, SIVA1 and TMEM40. Here, TMEM40 is linked to neoplasm.