In the adult rtTA/tet-Myc/tet-NICD cochlea explant treated with Dox transiently followed by ad-Atoh1 infection, we detected robust HC regeneration (MYO7A+/PVALB+) in the sensory epithelial region (SE), the limbus regions (Lib) (Fig. 5d), and from transdifferentiation of both dividing and non-dividing SCs (MYO7A+/SOX2+/EdU+ and MYO7A+/SOX2+/EdU−) (Arrows and arrowheads in Fig. 5d), respectively. This evidence concerns the gene SOX2 and infection.