Moreover, patients who are of Hp 2–2 genotype may benefit from this maneuver as compared with Hp 1–1 and Hp2-1, suggesting carnitine and tadalafil (PDE-5 inhibitor) may serve a prophylactic therapy approaches for CIN, especially in patients with Hp 2–2 genotype. The gene discussed is PDE5A; the disease is cervical squamous intraepithelial neoplasia.