WT1 and Wilms tumor: Mutations of the WT1 gene (Wilms Tumor transcription factor gene 1) are responsible for about 20% of Wilms tumor cases.22 In particular, WT1 is believed to regulator proto-oncogenes such as MYC in renal development.23 Thus, aberrant expression of WT1 can precipitate MYC-mediated cancers.