ERCC1 and lung carcinoma: Moreover, some polymorphic variants of these SNPs may affect the risk of lung cancer.23, 24, 25, 26, 27, 28 Yu et al revealed that NSCLC patients carrying the A/A genotype in rs3212986 of ERCC1 gene had a higher risk of lung cancer, especially in the smoking population.28 Zhou et al observed that rs3212986 ERCC1 gene polymorphism may be a useful predictor of OS in advanced NSCLC patients treated with platinum‐based chemotherapy.