This finding is consistent with previous studies demonstrating that the activation of NF‐κB/p65 directly regulated IL‐6 production and promoted inflammation.40, 41 Importantly, triptolide is currently in clinical use and was shown to be beneficial in mice models of polycystic kidney disease42 and pancreatic cancer in vitro and in vivo. This evidence concerns the gene NFKB1 and familial pancreatic carcinoma.