TGFB1I1 and glomerulosclerosis: First, Hic‐5 was shown to be a key link in the formation of ECM in the abnormal glomeruli of glomerular sclerosis.20 Hic‐5 was also found to be positively correlated with the expression of the hepatic stellate cells activation marker α‐smooth muscle actin (α‐SMA) during liver fibrosis.21 Furthermore, Hic‐5 plays a key role in disorders such as intestinal fibrosis by regulating the differentiation of myofibroblasts and the expression of ECM proteins.22 However, the mechanism underlying Hic‐5‐mediated regulation of CP has not been determined.