After infection with EV71, spinal muscles and hind leg muscles of mice, which express relative low level of SAMHD1 (Fig 4A–C), had higher levels of EV71 (> 60‐folds), whereas there was barely any virus in heart and lung (Fig 4D), which was consistent with previous findings showing that EV71 has a strong tropism to cause severe lesions in muscle tissues, but not in heart and lung tissues. The gene discussed is SAMHD1; the disease is infection.