Previously study showed that TGF‐β signaling pathway controls different biological processes and dysregulation of its canonical members is associated with different cancer types.24 In malignant B lymphocytes, TGF‐β signaling had been reported as a tumor suppressor.25, 26 TGFBR1, one of the receptor ligand of TGF‐β, transduces the TGF‐beta signaling through phosphorylating SMAD2/3 or no canonical downstream components.27 In our study, we demonstrated that miR‐27a might directly target TGFBR1 3′UTR. This evidence concerns the gene SMAD2 and cancer.