Altered genes abrogating other signaling pathways in ASL tumors in this cohort include Wnt/β-catenin signaling gene MED12 (Mediator Complex Subunit 12), and DNA damage response gene BRCA1. Both MED12 and BRCA2 were mutated in one ASL and one HCC tumor. The gene discussed is BRCA1; the disease is hepatocellular carcinoma.