Genes involved in the SWI/SNF (SWItch/Sucrose Non-Fermentable) nucleosome-remodeling complex (SRCAP and ARID4A) and other chromatin remodeling genes (TTF1, NUTM1, and PRDM16) were recurrently mutated in these HCC tumors. This evidence concerns the gene PRDM16 and hepatocellular carcinoma.