The Gene Ontology for biological process (GOBP), cellular components (GOCC) and molecular functions (GOMF) analysis revealed VEGF receptor signaling pathway, cell junction assembly, angiogenesis, NF-kB transcription activity, focal adhesion, actin cytoskeleton, PI3K complex, TLR-receptor binding and NAD(P)H oxidase activity as highly enriched processes in CCMs pathogenesis. This evidence concerns the gene NFKB1 and cerebrocostomandibular syndrome.