CCM2 and cerebral cavernous malformation: Interestingly, several co-expressed PCGs of LBX2-AS1 and SMIM25 map to CCM hotspot loci CCM1: 7q11-q22, CCM2: 7p15-13 and CCM3: 3q25.2-q27 with crucial functions that have relevance to CCM pathogenesis (Fig. 3a and Supplementary Data 3).