Among the total SMIM25-specific co-expressed PCGs, we identified FNDC3B, FYB1, AURKA, GMIP, COTL1, RETN, ARPC3, RPS6KA1, LSP1, VAV3, CD36, OS9, ETV6, MYO1F, GSTO1, ADAM9, PTAFR, LIMS1, CDK1, IRAK1, HSPA1A and CLDN23 to be involved in various molecular processes such as, oxidative stress, cell-cell adhesion, integrin signaling, angiogenesis, cell proliferation, MAP kinase pathway, endothelial cell dysfunction, RhoA-GTPase activity and PI3K signaling pathways that have been previously reported to be involved in CCMs disease. The gene discussed is LIMS1; the disease is cerebrocostomandibular syndrome.