For instance, the lectin isolated from Cratylia mollis (Cramoll) has been described as pro-inflammatory agent in in vitro and in vivo models18,61–63; however the treatment with this protein was shown to reduce the release of cytokines (such as TNF-α, IL-6) in experimental models of infection induced by S. aureus (using peritoneal cells)18 and Cryptococcus gatti (using mice)64. The gene discussed is TNF; the disease is infection.