That allows active TGF-β2 to bind to TGF-β receptors eliciting a cascade of events crucial for EC homeostasis40–42 but which also when unregulated can contribute to the development of fibrosis, cardiovascular disease, or may be usurped during tumor growth59; (2) TGF-β2 is also implicated in ECM protein production that is thought to lead to tissue remodeling and fibrosis characterized by ECM stiffening69. This evidence concerns the gene TGFB2 and cardiovascular disorder.