NOS2 and neoplasm: The most notable findings from our studies which provide evidence and new insights to the field include: (i) data showing a combination of AD and TS synergistically inhibits tumor growth and CSC number and activity in vitro and in vivo, (ii) the results of transcriptomic analyses which identified the Wnt/β-catenin pathway as crucial for lung CSC development and re-confirmed the importance of known targets such as Sox2, ALDH, and Nos2.