Strikingly, a point mutation in Banf1, alanine 12 to threonine (A12T), is associated with a severe premature ageing syndrome, Néstor–Guillermo progeria syndrome (NGPS), characterised by pathologies usually associated with ageing, such as generalised lipoatrophy and severe osteoporosis6,7. This evidence concerns the gene BANF1 and premature aging syndrome.