Strikingly, a point mutation in Banf1, alanine 12 to threonine (A12T), is associated with a severe premature ageing syndrome, Néstor–Guillermo progeria syndrome (NGPS), characterised by pathologies usually associated with ageing, such as generalised lipoatrophy and severe osteoporosis6,7. The gene discussed is BANF1; the disease is Nestor-Guillermo progeria syndrome.