Supplementary Figure 7a shows the top five gene pairs having the largest NMI values associated with each cancer type, further highlighting the co-occurrences of IDH1 with TP53, ATRX, and CIC in low grade glioma, and co-occurrences of CTNNB1 with PTEN and PIK3CA in endometrial cancer. The gene discussed is CTNNB1; the disease is central nervous system cancer.