Supplementary Figure 7a shows the top five gene pairs having the largest NMI values associated with each cancer type, further highlighting the co-occurrences of IDH1 with TP53, ATRX, and CIC in low grade glioma, and co-occurrences of CTNNB1 with PTEN and PIK3CA in endometrial cancer. This evidence concerns the gene TP53 and cancer.