IDH1 and cancer: Among all the observed variants in the 585 cancer genes annotated in OncoKB16, a repository of curated cancer genes, IDH1 R132H and BRAF V600E are the two most tissue-specific variants with NMIs of 0.18 and 0.13, respectively, followed by GTF21 L424H with an NMI of 0.08 (Supplementary Fig. 3).