CD4 and melanoma: In line with this notion, we found that the adverse macrophage types (M0, M1 and M2) and the favorable T cell subsets (CD8+ T cell and CD4+ memory resting T cell) account for a major fraction of the immune cells, and we noted the strong association among the fractions of the 22 immune cell subsets; these results further indicated that the features of the TME in melanoma are complicated and coordinated.