As shown in Table 2, high HIF-2α levels were significantly associated with tumour size (95%CI 1.611-8.178), tumour number (95%CI 1.289-22.174), alanine aminotransferase (95%CI 2.775-15.409) and age (95%CI 1.203-6.068). This evidence concerns the gene EPAS1 and neoplasm.