Moreover, increased expression levels of proteins associated with recognizing and modifying misfolded proteins, including HUGT2 and ER degradation-enhancing alpha-mannosidase-like protein 2 (EDEM2) but not HUGT1 were found in dorsolateral prefrontal brain cortex in schizophrenia (Kim et al. 2018). This evidence concerns the gene EDEM2 and schizophrenia.