MYBPC3 and cardiomyopathy: In preclinical experiments, Jiang et al. (2013) and Mearini et al. (2014) delivered an adeno-associated virus (AAV9) carrying Myh6 siRNA or Mybpc3 cDNA into the thoracic cavity or temporal vein of Myh6 or Mybpc3 mutant mice, respectively, relieving cardiomyopathy symptoms in both models.