Besides, mutations in a single sarcomere gene like cardiac troponin T (TNNT2) are sufficient to cause cardiomyopathy, and TNNT2 mutations are the most common ‘drivers’ of thin filament deficiency in both DCM and HCM (Hershberger et al., 2013; Veselka et al., 2017). Here, TNNT2 is linked to familial dilated cardiomyopathy.