NLRP3 and Abnormal renal physiology: Significantly higher renal tubular NLRP3 expression levels were detected in patients with severe renal dysfunction (eGFR < 60 ml/min/1.73 m2) than in patients with less severe renal dysfunction (eGFR ≥ 60 ml/min/1.73 m2) (0.042 ± 0.0171 vs 0.029 ± 0.0112, P = 0.034).