Tau oligomers associated with AD pathology have previously been reported to have diameters of 5–15 nm [50].To investigate the tau species in the EC of our Braak 0–I and Braak III–IV donors in more detail, we therefore immunoprecipitated tau with the Tau12 antibody and employed atomic force microscopy with quantitative image analysis. Here, MAPT is linked to Alzheimer disease.