CD4 and colitis: Moreover, flow cytometric analysis revealed that, compared to the GMSC group, iGMSCs showed significant reduced capacity to downregulate the elevated level of CD4+ IFN-γ+ T helper 1 (Th1) and CD4+ IL-17+ (Th17) cells and reduced level of CD4+ CD25+ Foxp3+ regulatory T cells (Tregs) in colitis mice at day 10 post-DSS induction (Fig. 2f–h).