TNF and cancer: The top KEGG pathways (Fig. 2b) were mainly enriched in MAPK signaling pathways, Proteoglycans in cancer, Breast cancer, IL-17 signaling pathway, TNF signaling pathway, Osteaclast differentiation, MicorRNAs in cancer, Human immunodeficiency virus 1 infection, Fluid shear stress and atherosclesosis, Ras signaling pathway, Hepatitis B, Regulation of action cytoskeleton, PI3K-Akt signaling pathway.