Interestingly, mutations in the WFS1 are not implicated only in the pathogenesis of classic Wolfram syndrome, but are also involved in the development of other WFS1-related disorders such as DFNA6/14/38 (OMIM #600965) non-syndromic low-frequency sensorineural hearing loss, non-syndromic autosomal-dominant diabetes, and Wolfram-like syndrome (OMIM #614296) [7–9]. Here, WFS1 is linked to Wolfram syndrome.