The absence of SCRN1 accumulation in pTau lesions present in the 4R-specific tauopathies CBD and PSP raised the possibility that SCRN1 preferentially colocalizes with 3R-tau isoforms, however the lack of SCRN1 accumulation in the 3R-tau specific PiD showed that this was not the case. This evidence concerns the gene SCRN1 and supranuclear palsy, progressive, 1.