SCRN1 and Alzheimer disease: In order to determine the physiological localization of SCRN1 and map the accumulation of SCRN1 throughout the progression of AD, we used immunohistochemistry to compare SCRN1 distribution in cases with high AD-associated NFT pathology (n = 21 cases), moderate AD-associated NFT pathology (n = 22) and in cognitively normal controls with little or no NFT pathology (n = 15).