This is supported by the finding that SCRN1 accumulation is present in AD, DS where co-occurrence of Aβ and Tau is observed, while it is not present in tau-only dementias (PSP, CBD, PiD) or in HCHWA-D that only has accumulation of Aβ. The gene discussed is MAPT; the disease is supranuclear palsy, progressive, 1.